Drug Standards
Selleck Chemical LLC Larotrectinib sulfate
Larotrectinib sulfate is an oral potent and selective ATP-competitive inhibitor of tropomyosin receptor kinases (TRK) Larotrectinib inhibition of TRKs induces cellular apoptosis and G1 cell-cycle arrest
Selleck Chemical LLC crizotinib
(S)-crizotinib the (S)-enantiomer of crizotinib is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay
Enzo Life Sciences Tamoxifen. citrate (1g). CAS: 54965-24-1
Antiestrogen with anti-cancer activity. Selective protein kinase C (PKC) inhibitor and induces PKC epsilon translocation. Induces apoptosis in estrogen receptor-negative human cancer cell lines. Alternative name: (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine . citrate. Purity: ≥99% (Assay). Appearance: White to off-white powder. Solubility: Soluble in methanol or ethanol; very slightly soluble in water or acetone. Long Term Storage: +4°C.
Cayman Chemical ErythromycIn lactobIonate 5g
A macrolide antibiotic and water-soluble form of erythromycin; active against S. aureus and S. pneumoniae, as well as clinical isolates of group A streptococci (MICs = 0.6, 0.06, and 0.031 UG/ml, respectively); increases survival and reduces the number of lung CFUs in a mouse model of S. pneumoniae-induced pneumonia at 50 mg/kg; increases survival in mice infected with P. aeruginosa at 50 or 100 mg/kg
Apexbio Technology LLC Econazole nitrate 24169-02-6 10mM (in 1mL DMSO)
Econazole nitrate (24169-02-6) is a small-molecule inhibitor targeting the enzyme 14 -demethylase It is designed to disrupt ergosterol synthesis in fungal membrane sterol biosynthesis thereby decreasing membrane integrity altering permeability and attenuating fungal cellular growth Econazole nitrate exerts its biological activity primarily through inhibition of 14 -demethylase In vitro studies demonstrate antifungal activity with reported IC50 values against various fungal isolates typically ranging from approximately 0 05 to 1 g/mL depending on experimental parameters and organism specificity Based on these pharmacological properties econazole nitrate holds research potential in antifungal susceptibility testing exploration of drug resistance mechanisms in fungal strains characterization of dermatopathogenic microorganisms and drug target identification studies
Apexbio Technology LLC Benazepril 86541-75-5 25mg
Benazepril (CAS 86541-75-5) is a small molecule inhibitor of angiotensin-converting enzyme (ACE) a key enzyme responsible for the conversion of angiotensin I to the vasoconstrictor angiotensin II By blocking ACE activity benazepril reduces the synthesis of angiotensin II leading to diminished vasoconstriction and lowered blood pressure In biomedical research benazepril is utilized to investigate the renin-angiotensin system cardiovascular regulation and mechanisms underlying hypertension Its pharmacological profile supports its application in studies focused on cardiovascular diseases and renal function